Pneumococcal Vaccine Clinical Trials

Pneumococcal disease is an infection caused by the bacteria Streptococcus pneumoniae, or pneumococcus. People can be infected with the bacteria, or they can carry it in their throat, and not be ill. Those carriers can still spread it, primarily in droplets from their nose or mouth when they breathe, cough, or sneeze.


Pneumococcal vaccines can prevent some cases of pneumonia, meningitis, and sepsis. Like all vaccines, it works with the body’s natural defenses to develop immunity to disease.


There are two kinds of these vaccines available in the United States:

  • Pneumococcal conjugate vaccine or PCV13
  • Pneumococcal polysaccharide vaccine or PPSV23

Vaccine clinical trials, like those at CNS Healthcare, can help you explore new vaccine options. Interested in trying a new vaccine at no cost? Find out more about enrolling vaccine clinical trials available by selecting one of the below locations near you. Use the form on the page to schedule a free, in-office consultation to find out if a vaccine trial is right for you. 

Find A Currently Enrolling Vaccine Clinical Trial Near You:

More About Pneumococcal Vaccine

The disease is contagious, meaning it spreads from person to person and causes thousands of infections every year in the United States. It’s more common in children, but it’s most likely to cause serious complications in adults. It can lead to different kinds of health problems — including serious infections in the lungs, lining of the brain and spinal cord, and blood. The good news is that vaccines can help prevent the disease.

Signs & Symptoms

There are many types of pneumococcal disease. Symptoms and complications depend on the part of the body that is infected.


Pneumococcal pneumonia (lung infection) is the most common serious form of this disease.  Symptoms include:

  • Fever and chills
  • Cough
  • Rapid breathing or difficulty breathing
  • Chest pain

Pneumococcal meningitis is an infection of the tissue covering the brain and spinal cord. Symptoms include:

  • Stiff neck
  • Fever
  • Headache
  • Photophobia (eyes being more sensitive to light)
  • Confusion

Pneumococcal bacteremia is a blood infection. Symptoms include:

  • Fever
  • Chills
  • Low alertness

Sepsis is a complication caused by the body’s overwhelming and life-threatening response to an infection, which can lead to tissue damage, organ failure, and death. Symptoms include:

  • Confusion or disorientation
  • Shortness of breath
  • High heart rate
  • Fever, shivering, or feeling very cold
  • Extreme pain or discomfort
  • Clammy or sweaty skin

Pneumococcus bacteria cause up to half of middle ear infections (otitis media). Symptoms include:

  • Ear pain
  • A red, swollen ear drum
  • Fever
  • Sleepiness