Pain-Related Clinical Trials

We can feel pain in almost any part of our bodies for a countless number of reasons. Some of the most common complaints for Americans are pain of the knee or lower-back, headaches, pain related to other medical disorders like shingles and diabetes, and pain related to mental health concerns like depression and anxiety.

The side effects and addictive qualities of pain medications are leading to research into new ways to treat pain without the risk of addiction or side effects, such as constipation. At CNS Healthcare we’re constantly working to offer new, more effective treatments with less side effects through our clinical trials for low back pain, knee pain, hip pain, and other pain-related disorders, such as fibromyalgiamigraine headaches and more.

Select from one of the below locations to find out if a low back pain, knee pain, or hip pain clinical trial is enrolling near you. Use the form on the page to schedule a free appointment to meet with one of our professionals who will help you determine if a pain-related clinical trial is right for you.

Find A Currently Enrolling Pain-Related Clinical Trial Near You:

More About Chronic Pain

Chronic knee pain is the most common of all the joint complaints in America. The latest estimates suggest that about 27 millions Americans report this problem. There are many possible causes including traumatic injury, repetitive movements like climbing or lifting, being overweight, injuries to other joints, and genetics. The most common type of knee pain is osteoarthritis. The discomfort can show up as stiffness, tenderness, trouble walking, difficulty going up stairs, and loss of flexibility. For most people with osteoarthritis in their knees, the stiffness occurs mainly in the morning or after sitting for long periods of time. As the day wears on, the discomfort generally lessens or goes away completely, until another episode of immobility (like sitting too long or sleeping), or exercise (any level of weight-bearing exercise) causes it to return.


Lower back pain is the most common cause of job-related disability in America and a leading reason that people miss work. Most episodes are caused by some sort of trauma to the lower back. This can include a car accident, a sports injury, or even just working around the house. For most people, the discomfort lasts just a few days, but for others, it becomes a constant part of their lives. Symptoms can range from sharp pain in a specific location to a dull ache that seems to spread. Any painful sensation that lasts for longer than 3 months is considered to be chronic.


Headaches are the most common neurological complaint in the United States. They can be a sign of other medical conditions like a sinus infection or meningitis, or can be completely unrelated to anything else as in the case of migraines. In order to figure out the best treatment option and to possibly reduce the number and frequency of headaches, it’s important to know the underlying cause. It’s often the case that treatment for a headache requires treating the underlying condition.


Pain can also be related to a number of mental health disorders including depression and anxiety. These can cause general feelings of discomfort throughout the body, but most commonly cause muscle tension in the back, neck and shoulders. These aches and pains, when coupled with the general loss of energy that also frequently comes with depression and anxiety, often prevent people from getting regular exercise or taking part in activities that they would otherwise enjoy. Both of these have been shown to reduce the symptoms of depression and anxiety. This can start a cycle of further decreases in energy, further reductions in exercise, increased physical pain and then more depression or anxiety.

Signs & Symptoms

  • Chronic Pain
  • Pain that does not go away as expected after an illness or injury
  • Pain that may be described as shooting, burning, aching, or electrical
  • Discomfort, soreness, tightness, or stiffness