Cardiovascular Disease Clinical Trials

Atherosclerotic Cardiovascular Disease is the thickening or hardening of the arteries. It is caused by a buildup of plaque in the inner lining of an artery. Chronic kidney disease (CKD) affects 11–13% of the world’s population and greatly increases risk of atherosclerotic cardiovascular disease (ASCVD) and death. It is characterized by systemic inflammation and disturbances in the blood leukocytes that remain incompletely understood. The coexistence of both CRD and ASCVD is highly prevalent.


Conventional ASCVD risk factors prevalent in CKD are managed by well-established methods including medication to control blood pressure, lipid parameters, and glucose in the blood. Other non-conventional ASCVD risk factors in CKD such as chronic inflammation do not yet have definitive treatments.  Cardiovascular disease with (ASCVD) and CKD Clinical Trials, like those at CNS Healthcare, can help you explore new options. Interested in trying a new ASCVD and CKD treatment at no cost? Find out more about enrolling ASCVD and CKD trials available by selecting the below location near you. Use the form on the page to schedule a free, in-office consultation to find out if a trial is right for you.

Find A Currently Enrolling Cardiovascular Disease Clinical Trial Near You:

More About Cardiovascular Disease

Atherosclerotic Cardiovascular Disease is a slow, progressive disease that may begin as early as childhood. Although the exact cause is unknown, ASCVD may start with damage or injury to the inner layer of an artery. The damage may be caused by high blood pressure, high cholesterol, high triglycerides, a type of fat (lipid) in your blood, smoking, insulin resistance, obesity or diabetes and inflammation from an unknown cause or from diseases such as arthritis, lupus, psoriasis or inflammatory bowel disease.


Chronic kidney disease, also called chronic kidney failure, describes the gradual loss of kidney function. Your kidneys filter wastes and excess fluids from your blood, which are then excreted in your urine. When chronic kidney disease reaches an advanced stage, dangerous levels of fluid, electrolytes and wastes can build up in your body.

Signs & Symptoms

You usually won’t have atherosclerosis ASCVD symptoms until an artery is so narrowed or clogged that it can’t supply enough blood to your organs and tissues. Sometimes a blood clot completely blocks blood flow, or even breaks apart and can trigger a heart attack or stroke.


Symptoms of moderate to severe ASCVD depend on which arteries are affected. For example:

  • If you have atherosclerosis in your heart arteries,you may have symptoms, such as chest pain or pressure (angina).
  • If you have atherosclerosis in the arteries leading to your brain,you may have signs and symptoms such as sudden numbness or weakness in your arms or legs, difficulty speaking or slurred speech, temporary loss of vision in one eye, or drooping muscles in your face.
  • If you have atherosclerosis in the arteries in your arms and legs,you may have signs or symptoms of peripheral artery disease, such as leg pain when walking (claudication) or decreased blood pressure in an affected limb.
  • If you have atherosclerosis in the arteries leading to your kidneys,you develop high blood pressure or kidney failure.


Signs and symptoms of chronic kidney disease develop over time if kidney damage progresses slowly. Signs and symptoms of kidney disease may include:

  • Nausea
  • Vomiting
  • Loss of appetite
  • Fatigue and weakness
  • Sleep problems
  • Changes in how much you urinate
  • Decreased mental sharpness
  • Muscle twitches and cramps
  • Swelling of feet and ankles
  • Persistent itching
  • Chest pain, if fluid builds up around the lining of the heart
  • Shortness of breath, if fluid builds up in the lungs
  • High blood pressure (hypertension) that’s difficult to control